7-deazaguanosine

Names

[ Name ]:
7-deazaguanosine

[Synonym ]:
7-Desazaguanosin
PELDESINE
BCX-34

Biological Activity

[Description]:

7-Deazaguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.06g/cm3

[ Boiling Point ]:
668.3ºC at 760mmHg

[ Melting Point ]:
>250ºC dec

[ Molecular Formula ]:
C₁₁H₁₄N₄O₅

[ Molecular Weight ]:
282.25

[ Flash Point ]:
358ºC

[ Exact Mass ]:
282.09600

[ PSA ]:
146.62000

[ Index of Refraction ]:
1.874

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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