Duoperone

Names

[ CAS No. ]:
62030-88-0

[ Name ]:
Duoperone

[Synonym ]:
Duoperonum [Latin]
DUOPERONE FUMARATE
(4-fluoro-phenyl)-{1-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperidin-4-yl}-methanone
Duoperona
2-trifluoromethyl-10-{3-[4-(p-fluorobenzoyl)piperidinyl]propyl}phenothiazine
UNII-E84FJ4KW3B
Duoperone
Duoperona [Spanish]
Duoperonum
Duoperone [INN]
Duoperone fumarate [USAN]

Biological Activity

[Description]:

Duoperone is a neuroleptic agent and also a antiemetic agent in animal models.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vivo]

Duoperone blocks d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval is between one hour and seven days. ABR-6646 produces catalepsy in rats. The onset of this effect is delayed and the duration is prolonged when compared with that of chlorpromazine. Apomorphine-induced pivoting in mice with unilateral lesions of the caudate nucleus is suppressed by ARR-6646[1].

[References]

[1]. Johnson DN, et al. AHR-6646: a new, long-acting neuroleptic. Prog Neuropsychopharmacol. 1979;3(5-6):513-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.289g/cm3

[ Boiling Point ]:
613.5ºC at 760 mmHg

[ Molecular Formula ]:
C₂₈H₂₆F₄N₂OS

[ Molecular Weight ]:
514.57700

[ Flash Point ]:
324.8ºC

[ Exact Mass ]:
514.17000

[ PSA ]:
48.85000

[ LogP ]:
7.43510

[ Index of Refraction ]:
1.587

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Related Compounds

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