Norarecoline Hydrochloride

Names

[ Name ]:
Norarecoline Hydrochloride

[Synonym ]:
methyl 1,2,5,6-tetrahydropyridine-3-carboxylate hydrochloride
Guvacoline hydrochloride
methyl 1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrochloride
Norarecoline hydrochloride
Norarecoline HCl
3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro-,methyl ester,hydrochloride
Guvacine methyl ester hydrochloride
1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid methyl ester hydrochloride
methyl 1,2,3,6-tetrahydropyridine-5-carboxylate hydrochloride
guvacine methyl esther hydrocloride

Biological Activity

[Description]:

Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> mAChR

[References]

[1]. Jiao Wu, et al. Tissue-specific and maturity-dependent distribution of pyridine alkaloids in Areca triandra. J Plant Res. 2019 Jul;132(4):531-540.

[2]. M Wolf-Pflugmann, et al. Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester. Arzneimittelforschung. 1989 May;39(5):539-44.

Chemical & Physical Properties

[ Boiling Point ]:
209.1ºC at 760 mmHg

[ Melting Point ]:
121-122 ºC

[ Molecular Formula ]:
C₇H₁₂ClNO₂

[ Molecular Weight ]:
177.62900

[ Flash Point ]:
80.2ºC

[ Exact Mass ]:
177.05600

[ PSA ]:
38.33000

[ LogP ]:
1.20990

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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