DC Chemicals Limited
China
Product Name: Guvacoline hydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Methyl 1,2,5,6-Tetrahydropyridine-3-carboxylate Hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

6197-39-3

6197-39-3 structure

6197-39-3 structure

Name: Norarecoline Hydrochloride
Chemical Name: methyl 1,2,3,6-tetrahydropyridine-5-carboxylate,hydrochloride
CAS Number: 6197-39-3
Molecular Formula: C₇H₁₂ClNO₂
Molecular Weight: 177.62900
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2017-03-23 11:25:45
Modify Date: 2024-01-06 11:00:21
Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors[1][2].

Name	methyl 1,2,3,6-tetrahydropyridine-5-carboxylate,hydrochloride
Synonyms	methyl 1,2,5,6-tetrahydropyridine-3-carboxylate hydrochloride Guvacoline hydrochloride methyl 1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrochloride Norarecoline hydrochloride Norarecoline HCl 3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro-,methyl ester,hydrochloride Guvacine methyl ester hydrochloride 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid methyl ester hydrochloride methyl 1,2,3,6-tetrahydropyridine-5-carboxylate hydrochloride guvacine methyl esther hydrocloride

Description	Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> mAChR
References	[1]. Jiao Wu, et al. Tissue-specific and maturity-dependent distribution of pyridine alkaloids in Areca triandra. J Plant Res. 2019 Jul;132(4):531-540. [2]. M Wolf-Pflugmann, et al. Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester. Arzneimittelforschung. 1989 May;39(5):539-44.

Boiling Point	209.1ºC at 760 mmHg
Melting Point	121-122 ºC
Molecular Formula	C₇H₁₂ClNO₂
Molecular Weight	177.62900
Flash Point	80.2ºC
Exact Mass	177.05600
PSA	38.33000
LogP	1.20990
Storage condition	2-8℃

HS Code	2933399090

63-75-2 structure

63-75-2

~92%

6197-39-3 structure

6197-39-3

Literature: Rosenau, Thomas; Hofinger, Andreas; Potthast, Antje; Kosma, Paul Organic Letters, 2004 , vol. 6, # 4 p. 541 - 544

300-08-3 structure

300-08-3

~%

6197-39-3 structure

6197-39-3

Literature: Long, Sha; Stefani, Francesca Romana; Biondi, Stefano; Ghiselli, Giancarlo; Panunzio, Mauro Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5811 - 5822

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%