Cremophor EL

Names

[ Name ]:
Cremophor EL

[Synonym ]:
MFCD00130879
1,3-Dichlor-2-propanylcarbamat
Carbamate de 1,3-dichloro-2-propanyle
2-Propanol, 1,3-dichloro-, carbamate
1,3-dichloropropan-2-yl carbamate
1,3-Dichloro-2-propanyl carbamate
Castor oil ethoxylated
Polyoxyethylene castor oil

Biological Activity

[Description]:

Cremophor EL is a polyethoxylated surfactant.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Biochemical Assay Reagents

Research Areas >> Others

[In Vitro]

Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment[1].

[Cell Assay]

Cell viability is determined by double fluorescent staining: bis-benzimide labels all cell nuclei, ethidium-homodimer-1 stains only dead cells. For morphological examinations, primary brain endothelial cells with tight barrier properties are used. Cells grown on glass coverslips are treated with Cremophor EL and RH40 for 1 and 24 h. Cremophor EL and RH40 are tested at 0.1 to 50 mg/mL concentrations. Triton X-100 detergent (10 mg/mL) is used in toxicity assays as a reference compound to cause cell death[1].

[References]

[1]. Kiss L, et al. Kinetic analysis of the toxicity of pharmaceutical excipients Cremophor EL and RH40 on endothelial and epithelial cells. J Pharm Sci. 2013 Apr;102(4):1173-81.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
305.7±32.0 °C at 760 mmHg

[ Melting Point ]:
4°C

[ Molecular Formula ]:
C₄H₇Cl₂NO₂

[ Molecular Weight ]:
172.010

[ Flash Point ]:
138.7±25.1 °C

[ Exact Mass ]:
170.985382

[ LogP ]:
0.62

[ Appearance of Characters ]:
Viscous Liquid | Clear yellow

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.481

[ Storage condition ]:
REFRIGERATOR (+4C)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
GO5661000

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