Benzo[g]pteridine-2,4(3H,10H)-dione, 10-(2-methoxyethyl)-3-phenyl-

Names

[ Name ]:
Benzo[g]pteridine-2,4(3H,10H)-dione, 10-(2-methoxyethyl)-3-phenyl-

Biological Activity

[Description]:

NSC 288387 is a pan-flavivirus MTase inhibitor. NSC 288387 binds to the SAM-binding pocket. NSC 288387 inhibits ZIKV with an IC50 of 0.2 μM. NSC 288387 also inhibits viral replication in cell culture[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Samrat SK, et al. Broad-Spectrum Small-Molecule Inhibitors Targeting the SAM-Binding Site of Flavivirus NS5 Methyltransferase. ACS Infect Dis. 2023 Jul 14;9(7):1319-1333.

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
508.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₆N₄O₃

[ Molecular Weight ]:
348.36

[ Flash Point ]:
261.5ºC

[ Exact Mass ]:
348.12200

[ PSA ]:
79.01000

[ LogP ]:
1.74200

[ Index of Refraction ]:
1.682

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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