mycaminosyltylonolide

Names

[ Name ]:
mycaminosyltylonolide

[Synonym ]:
5-O-mycaminosyltylonolid
O-mycaminosyltylonolide
Mycaminosyltylonolide
2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde

Biological Activity

[Description]:

Mycaminosyltylonolide is a potent antibiotic. Mycaminosyltylonolide shows antibacterial activity. Mycaminosyltylonolide inhibits luciferase synthesis[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Mycaminosyltylonolid (3 µM) 抑制 E. coli S30 中的萤火虫荧光素酶 mRNA 翻译[1]。 Mycaminosyltylonolid (0-128 µg/mL) 具有抗菌活性，对 S. aureus FDA209Pa, S. aureus Smitha, S. aureus KUB857c, S. epidermidis KUB795g, E. faecalis ATCC29212h, K. pneumoniae NCTC9632h 的 MIC 值分别为 1、1、2、2、1、64 µg/mL[2]。

[References]

[1]. Shishkina A, et al. Conjugates of amino acids and peptides with 5-o-mycaminosyltylonolide and their interaction with the ribosomal exit tunnel. Bioconjug Chem. 2013 Nov 20;24(11):1861-9.

[2]. Sugawara A, et al. 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity. J Antibiot (Tokyo). 2017 Jul;70(8):878-887.

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Boiling Point ]:
799.9ºC at 760 mmHg

[ Molecular Formula ]:
C₃₁H₅₁NO₁₀

[ Molecular Weight ]:
597.73700

[ Flash Point ]:
437.6ºC

[ Exact Mass ]:
597.35100

[ PSA ]:
163.06000

[ LogP ]:
1.40240

[ Index of Refraction ]:
1.545

Related Compounds

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