61257-02-1

61257-02-1 structure

Name: mycaminosyltylonolide
Chemical Name: 5-O-mycaminosyltylonolide
CAS Number: 61257-02-1
Molecular Formula: C₃₁H₅₁NO₁₀
Molecular Weight: 597.73700
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-05-20 11:15:16
Modify Date: 2024-02-04 12:20:42
Mycaminosyltylonolide is a potent antibiotic. Mycaminosyltylonolide shows antibacterial activity. Mycaminosyltylonolide inhibits luciferase synthesis[1][2].

Name	5-O-mycaminosyltylonolide
Synonyms	5-O-mycaminosyltylonolid O-mycaminosyltylonolide Mycaminosyltylonolide 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-(hydroxymethyl)-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde

Description	Mycaminosyltylonolide is a potent antibiotic. Mycaminosyltylonolide shows antibacterial activity. Mycaminosyltylonolide inhibits luciferase synthesis[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Mycaminosyltylonolid (3 µM) 抑制 E. coli S30 中的萤火虫荧光素酶 mRNA 翻译[1]。 Mycaminosyltylonolid (0-128 µg/mL) 具有抗菌活性，对 S. aureus FDA209Pa, S. aureus Smitha, S. aureus KUB857c, S. epidermidis KUB795g, E. faecalis ATCC29212h, K. pneumoniae NCTC9632h 的 MIC 值分别为 1、1、2、2、1、64 µg/mL[2]。
References	[1]. Shishkina A, et al. Conjugates of amino acids and peptides with 5-o-mycaminosyltylonolide and their interaction with the ribosomal exit tunnel. Bioconjug Chem. 2013 Nov 20;24(11):1861-9. [2]. Sugawara A, et al. 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity. J Antibiot (Tokyo). 2017 Jul;70(8):878-887.