Quinine Hydrochloride Dihydrate

Names

[ Name ]:
Quinine Hydrochloride Dihydrate

[Synonym ]:
Quinine hydrochloride,(R)-(6-Methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanolhydrochloride
EINECS 231-437-7
MFCD00151248
Quinine monohydrochloride dihydrate
Quinine Hydrochloride Dihydrate
Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-, hydrochloride, hydrate (1:1:2)
(8α,9R)-6'-Methoxycinchonan-9-ol hydrochloride dihydrate
Quinine (hydrochloride dihydrate)

Biological Activity

[Description]:

Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.Target: AntiparasiticQuinine is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine, which, unlike quinine, is an antiarrhythmic. Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine. In patients with cerebral malaria receiving the standard dose of 10 mg/kg every eight hours, plasma quinine concentrations consistently exceeded 10 mg/liter, reaching a peak 60 ± 25 hours (mean ± 1 S.D.) after treatment was begun and then declining. Quinine total clearances (CI) and total apparent volumes of distribution (Vd) were significantly lower than in uncomplicated malaria (CI, 0.92 ± 0.42 compared with 1.35 ± 0.6 ml/min/kg, p = 0.03; Vd, 1.18 ± 0.37 compared with 1.67 ± 0.34 liter/kg, p = 0.0013) [1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[References]

[1]. White, N.J., et al., Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med, 1982. 73(4): p. 564-72.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
633ºC at 760 mmHg

[ Melting Point ]:
115-116 °C (dec.)(lit.)

[ Molecular Formula ]:
C₂₀H₂₉ClN₂O₄

[ Molecular Weight ]:
396.908

[ Flash Point ]:
122 °C

[ Exact Mass ]:
396.181580

[ PSA ]:
64.05000

[ LogP ]:
3.78450

[ Index of Refraction ]:
-250 ° (C=2, EtOH)

[ Storage condition ]:
Store at -20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H317-H334

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S22-S36/37-S45-S36/37/39-S26

[ RIDADR ]:
1544

[ WGK Germany ]:
3

[ RTECS ]:
VA7700000

[ HS Code ]:
29392000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29392000

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NAMI-A is a novel ruthenium complex with selective activity against metastases currently in Phase I clinical trials in The Netherlands. The photostability of this new agent in solid state and in solut...

Quinine blocks a calcium-activated potassium conductance in mammalian enteric neurones.

Br. J. Pharmacol. 83(1) , 3-5, (1984)

Quinine (100 microM) abolished the slow calcium-dependent afterhyperpolarization which occurs after an action potential in some neurones of the guinea-pig myenteric and submucous plexus. This occurred...

Treatment of severe malaria.

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In the treatment of severe Plasmodium falciparum infection antimalarial drugs should, ideally, be given by controlled rate intravenous infusion until the patient is able to swallow tablets. In cases w...