Dansyl chloride

Names

[ CAS No. ]:
605-65-2

[ Name ]:
Dansyl chloride

[Synonym ]:
5-(Dimethylamino)naphthalene-1-sulfonyl chloride
EINECS 210-092-6
5-(Dimethylamino)-1-naphthalenesulfonyl chloride
MFCD00003985
1-chlorosulfonyl-5-(dimethylamino)naphthalene
Dansyl chloride
1-Naphthalenesulfonyl chloride, 5-(dimethylamino)-

Biological Activity

[Description]:

Dansyl chloride is a reagent that reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green-fluorescent sulfonamide adducts. Dansyl chloride is widely used to modify amino acids; specifically, protein sequencing and amino acid analysis. It can also be used to label hydroxyl and carboxylic acid functional groups.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
371.3±22.0 °C at 760 mmHg

[ Melting Point ]:
72-74 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₂ClNO₂S

[ Molecular Weight ]:
269.747

[ Flash Point ]:
178.4±22.3 °C

[ Exact Mass ]:
269.027740

[ PSA ]:
45.76000

[ LogP ]:
3.67

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
acetone: 50 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK3688000

CHEMICAL NAME :: 1-Naphthalenesulfonyl chloride, 5-(dimethylamino)-

CAS REGISTRY NUMBER :: 605-65-2

BEILSTEIN REFERENCE NO. :: 2217205

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H12-Cl-N-O2-S

MOLECULAR WEIGHT :: 269.76

WISWESSER LINE NOTATION :: L66J BSWG GN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00262

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
QK3688000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29214980

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921199090

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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