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Chrysosplenetin

Names

[ CAS No. ]:
603-56-5

[ Name ]:
Chrysosplenetin

[Synonym ]:
Chrysosplenetin
4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-
5,3'-Dipropyl-biphenyl-2,4'-diol
chrysoplenitin
4',5-dihydroxy-3,6,7,3'-tetramethoxyflavone
3,6,7,3'-tetra-methylquercetagetin
5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-chromen-4-one
Tetrahydrohonokiol
Chrysosplenetin B
Tetrahydrohoenokiol
chrysosplenol B
Quercetagetin 3,6,7,3'-tetramethyl ether
5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-chrom en-4-one

Biological Activity

[Description]:

Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
Research Areas >> Metabolic Disease

[Target]

CYP3A


[References]

[1]. Ma L, et al. Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine. Pharm Biol. 2017 Dec;55(1):374-380.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
615.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H18O8

[ Molecular Weight ]:
374.341

[ Flash Point ]:
222.7±25.0 °C

[ Exact Mass ]:
374.100159

[ PSA ]:
107.59000

[ LogP ]:
2.26

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.640

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds