Thiocillin I

Names

[ Name ]:
Thiocillin I

[Synonym ]:
g-15-ii

Biological Activity

[Description]:

Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Bacterial[1]

[In Vitro]

Thiocillin I (2 μM; 24 hours; U-2OS C3 osteosarcoma cells) is not proteasome inhibitor, and does not stabilize expression of multiple cellular proteins and suppresses FoxM1 expression in U-2OS C3 osteosarcoma cells[2].

[References]

[1]. Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst. Chem Sci. 2018 Dec 3;10(7):1971-1975.

[2]. Pandit B, et al. Proteasome inhibitory activity of thiazole antibiotics. Cancer Biol Ther. 2011 Jan 1;11(1):43-7.

Chemical & Physical Properties

[ Density]:
1.456g/cm3

[ Molecular Formula ]:
C₄₈H₄₉N₁₃O₁₀S₆

[ Molecular Weight ]:
1160.37000

[ Exact Mass ]:
1159.20000

[ PSA ]:
536.13000

[ LogP ]:
6.40510

[ Index of Refraction ]:
1.659

Synthetic Route

Click to get detail synthetic route

Related Compounds

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