59979-01-0

59979-01-0 structure

Name: Thiocillin I
Chemical Name: Thiocillin I
CAS Number: 59979-01-0
Molecular Formula: C₄₈H₄₉N₁₃O₁₀S₆
Molecular Weight: 1160.37000
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-03-30 08:00:00
Modify Date: 2024-01-16 22:40:08
Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively[1].

Name	Thiocillin I
Synonyms	g-15-ii

Description	Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Bacterial[1]
In Vitro	Thiocillin I (2 μM; 24 hours; U-2OS C3 osteosarcoma cells) is not proteasome inhibitor, and does not stabilize expression of multiple cellular proteins and suppresses FoxM1 expression in U-2OS C3 osteosarcoma cells[2].
References	[1]. Akasapu S, et al. Total synthesis of micrococcin P1 and thiocillin I enabled by Mo(vi) catalyst. Chem Sci. 2018 Dec 3;10(7):1971-1975. [2]. Pandit B, et al. Proteasome inhibitory activity of thiazole antibiotics. Cancer Biol Ther. 2011 Jan 1;11(1):43-7.