MtbHU-IN-1

Names

[ Name ]:
MtbHU-IN-1

Biological Activity

[Description]:

MtbHU-IN-1 is an inhibitor of Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU), with a Kd of 98 nM for binding to WT MtbHU.

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Kd: 98 nM (WT MtbHU )[1].

[In Vitro]

MtbHU-IN-1 (SD4) is an inhibitor of Mycobacterium tuberculosis nucleoid-associated protein HU (MtbHU), with Kds of 98 nM, 760 nM, 980 nM, 340 nM and 730 nM for WT and mutant MtbHUs, respectively[1].

[References]

[1]. Bhowmick T, et al. Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors. Nat Commun. 2014 Jun 11;5:4124.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₄H₃₆N₄O₁₂S₂

[ Molecular Weight ]:
876.91

Related Compounds

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