Bis-PEG1-acid

Names

[ Name ]:
Bis-PEG1-acid

[Synonym ]:
3,3'-oxydipropanoic acid
3-(2-carboxyethyloxy)propanoic acid
3-(2-carboxyethoxy)propionic acid
4-oxa-heptanedioic acid
3,3'-oxydipropionic acid
4-oxa-1,7-heptanedioic acid
4-Oxaheptandisaure

Biological Activity

[Description]:

Bis-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.316g/cm3

[ Boiling Point ]:
371.4ºC at 760 mmHg

[ Melting Point ]:
60-61°C(lit.)

[ Molecular Formula ]:
C₆H₁₀O₅

[ Molecular Weight ]:
162.14100

[ Flash Point ]:
158.7ºC

[ Exact Mass ]:
162.05300

[ PSA ]:
83.83000

[ Index of Refraction ]:
1.475

Safety Information

[ Hazard Codes ]:
C

Bis-PEG1-acid

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds