p-chloromercuribenzoic acid
Names
[ CAS No. ]:
59-85-8
[ Name ]:
p-chloromercuribenzoic acid
[Synonym ]:
MFCD00002526
4-Carboxy-phenylquecksilber(1+),Chlorid
PARA-CHLOROMERCURIBENZOICACID
P-CMB
P-CHLOROMERCURIBENZOIC ACID
4-(chloromercuri) benzoic acid
p-Chlormercuribenzoic Acid
4-Chloromercurio-benzoesaeure
EINECS 200-442-6
p-(chloromercuri)-benzoicaci
p-chloromercury(II)benzoic acid
p-chloro-mercuricbenzoicacid
4-CHLOROMERCURIBENZOIC ACID
usafd-3
P-CMBA
4-carboxy-phenylmercury (1+),chloride
Chemical & Physical Properties
[ Melting Point ]:
287 °C (dec.)(lit.)
[ Molecular Formula ]:
C7H5ClHgO2
[ Molecular Weight ]:
357.15600
[ Exact Mass ]:
357.96800
[ PSA ]:
37.30000
[ LogP ]:
1.24640
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OV8050000
- CHEMICAL NAME :
- Mercury, (p-carboxyphenyl)chloro-
- CAS REGISTRY NUMBER :
- 59-85-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 22
- MOLECULAR FORMULA :
- C7-H4-Cl-Hg-O2.H
- MOLECULAR WEIGHT :
- 357.16
- WISWESSER LINE NOTATION :
- QVR D-HG-G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** REVIEWS *** ACGIH TLV-TWA 0.1 mg(Hg)/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3 DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,22,1973 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-FRANCE:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993 OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993 OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-POLAND:TWA 0.01 mg(Hg)/m3 JAN 1993 OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993 OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
Safety Information
[ Symbol ]:
GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310 + H330-H373-H410
[ Precautionary Statements ]:
P260-P273-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310
[ Hazard Codes ]:
T+,N
[ Risk Phrases ]:
R26/27/28;R33
[ Safety Phrases ]:
S13-S28-S36-S45-S60-S61
[ RIDADR ]:
UN 2025 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
OV8050000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
Precursor & DownStream
Precursor
DownStream
Articles
Nat. Chem. Biol. 5 , 765-71, (2009)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...
Reinvestigation of drugs and chemicals as aquaporin-1 inhibitors using pressure-induced hemolysis in human erythrocytes.Biol. Pharm. Bull. 35(11) , 2088-91, (2012)
Recently, we have found that pressure-induced hemolysis is enhanced by inhibiting water transport via aquaporin-1 (AQP1), as seen in p-chloromercuribenzoate (pCMB)-treated erythrocytes. So, using this...
Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria.Antimicrob. Agents Chemother. 53 , 5279-83, (2009)
In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a s...