C7280948

Names

[ Name ]:
C7280948

[Synonym ]:
sulfanilic acid phenethylamide
Sulfanilsaeure-phenaethylamid
4-amino-N-phenethylbenzenesulfonamide
4-Amino-N-(2-phenylethyl)benzenesulfonamide
Benzenesulfonamide, 4-amino-N-(2-phenylethyl)-
C7280948
C-7280948

Biological Activity

[Description]:

C-7280948 is a PRMT1 inhibitor.IC50 value:Target: PRMT1in vitro: Especially arginine methyltransferases also target non-histone protein substrates and are therefore often called protein methyltransferases (PRMTs). The subtype PRMT1 has been linked to the activation of estrogen and androgen receptors and therefore may represent a new treatment option for hormone-dependent cancer. C-7280948 is a inhibitor, which is available for PRMT1.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

Research Areas >> Others

[References]

[1]. Bissinger EM, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011 Jun 15;19(12):3717-3731.

[Related Small Molecules]

GSK126 | Tazemetostat (EPZ-6438) | UNC 0642 | GSK343 | Pinometostat (EPZ5676) | 3-Deazaneplanocin A (hydrochloride) | Pemrametostat (GSK3326595) | UNC1999 | BIX-01294 | EPZ031686 | AZ505 (ditrifluoroacetate) | MS023 | EPZ 004777 | EPZ015666 | EPZ015866(GSK591)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
481.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₆N₂O₂S

[ Molecular Weight ]:
276.354

[ Flash Point ]:
244.8±31.5 °C

[ Exact Mass ]:
276.093262

[ PSA ]:
80.57000

[ LogP ]:
2.18

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.617

[ Storage condition ]:
-20℃

Safety Information

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%