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Licochalcone B

Names

[ CAS No. ]:
58749-23-8

[ Name ]:
Licochalcone B

[Synonym ]:
2-methoxy-3,4,4'-trihydroxychalcone
Licochalcone B
Licochalcon B
(2E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
2-Propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
licochalcone

Biological Activity

[Description]:

Licochalcone B is an extract from the root of Glycyrrhiza inflate. Licochalcone B inhibits amyloid β (Aβ42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ions[1].

[References]

[1]. Cao Y, et al. Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease. Nat Prod Res. 2018 Oct 22:1-4.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
550.5±50.0 °C at 760 mmHg

[ Melting Point ]:
196-197ºC

[ Molecular Formula ]:
C16H14O5

[ Molecular Weight ]:
286.279

[ Flash Point ]:
208.5±23.6 °C

[ Exact Mass ]:
286.084137

[ PSA ]:
86.99000

[ LogP ]:
2.57

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.684

[ Storage condition ]:
2-8C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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