Amino-PEG4-Boc

Names

[ Name ]:
Amino-PEG4-Boc

[Synonym ]:
15-AMINO-4,7,10,13-TETRAOXA-PENTADECANOIC ACID T-BUTYL ESTER
1-AMINO-3,6,9,12-BUTAOXAPENTADECAN-15-OIC ACID t-Butyl ester
tert-butyl 15-amino-4,7,10,13-tetraoxapentadecanoate
ter-butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate
15-Amino-4,7,10,13-tetraoxa-pentadecanoic-acid-tert-butylester
Amino-PEG4-t-butyl ester
AmbotzPEG1375
2-[2-[2-[2-(2-tert-Butoxycarbonylethoxy)ethoxy]ethoxy]ethoxy]ethylamine
H2N-PEG4-CH2CH2COOtBu

Biological Activity

[Description]:

Amino-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.040±0.06 g/cm3

[ Boiling Point ]:
400.1±35.0 ºC (760 Torr)

[ Molecular Formula ]:
C₁₅H₃₁NO₆

[ Molecular Weight ]:
321.41000

[ Flash Point ]:
114.1±22.3 ºC

[ Exact Mass ]:
321.21500

[ PSA ]:
89.24000

[ LogP ]:
1.44360

[ Water Solubility ]:
Freely soluble (140 g/L) (25 ºC)

Synthetic Route

Click to get detail synthetic route

Related Compounds

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