Amino-PEG4-hydrazide-Boc

Names

[ Name ]:
Amino-PEG4-hydrazide-Boc

[Synonym ]:
7,10,13,16-Tetraoxa-2,3-diazaoctadecan-1-oic acid, 18-amino-4-oxo-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl 18-amino-4-oxo-7,10,13,16-tetraoxa-2,3-diazaoctadecan-1-oate

Biological Activity

[Description]:

Amino-PEG4-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Molecular Formula ]:
C₁₆H₃₃N₃O₇

[ Molecular Weight ]:
379.449

[ Exact Mass ]:
379.231842

[ LogP ]:
-1.25

[ Index of Refraction ]:
1.474

Amino-PEG4-hydrazide-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds