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2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol dihydrochloride

Names

[ CAS No. ]:
58045-23-1

[ Name ]:
2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol dihydrochloride

[Synonym ]:
(Z)-4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]piperazine-1-ethanol dihydrochloride

Biological Activity

[Description]:

Zuclopenthixol ((Z)-Clopenthixol) dihydrochloride is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist. Zuclopenthixol dihydrochloride is used in the study of schizophrenia[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[Target]

D2 Receptor


[References]

[1]. Khalifa AE, et al. Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. Hum Exp Toxicol. 2004 Aug;23(9):439-45.  

[2]. Manzaneque JM, et al. An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21(1):11-5.  

[3]. Bryan EJ, et al. Zuclopenthixol dihydrochloride for schizophrenia. Cochrane Database Syst Rev. 2017 Nov 16;11(11):CD005474.   

Chemical & Physical Properties

[ Boiling Point ]:
577.4ºC at 760 mmHg

[ Molecular Formula ]:
C22H27Cl3N2OS

[ Molecular Weight ]:
473.89

[ Flash Point ]:
303ºC

[ Exact Mass ]:
436.11400

[ PSA ]:
52.01000

[ LogP ]:
4.91410

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL8575250
CHEMICAL NAME :
1-Piperazineethanol, 4-(3-(2-chloro-9H-thioxanthen-9-ylidene)propyl)-, dihydrochloride, (Z)-
CAS REGISTRY NUMBER :
58045-23-1
LAST UPDATED :
199106
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H25-Cl-N2-O-S.2Cl-H
MOLECULAR WEIGHT :
473.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
105 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3996211

Related Compounds

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