bromoanisole

Names

[ CAS No. ]:
578-57-4

[ Name ]:
bromoanisole

[Synonym ]:
2-Bromoanisole
2-Bromophenyl methyl ether
Benzene, 1-bromo-2-methoxy-
bromoanisole
1-Bromo-2-methoxybenzene
EINECS 209-425-8
MFCD00000064

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
216.0±0.0 °C at 760 mmHg

[ Melting Point ]:
2 °C(lit.)

[ Molecular Formula ]:
C₇H₇BrO

[ Molecular Weight ]:
187.034

[ Flash Point ]:
96.7±0.0 °C

[ Exact Mass ]:
185.968018

[ PSA ]:
9.23000

[ LogP ]:
2.70

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.539

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8500000

CHEMICAL NAME :: Anisole, o-bromo-

CAS REGISTRY NUMBER :: 578-57-4

BEILSTEIN REFERENCE NO. :: 1859996

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H7-Br-O

MOLECULAR WEIGHT :: 187.05

WISWESSER LINE NOTATION :: ER BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2466 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(12),19,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1544 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(12),19,1979

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
N:Dangerousfortheenvironment;

[ Risk Phrases ]:
51/53

[ Safety Phrases ]:
S61-S24/25

[ RIDADR ]:
UN 3082 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
BZ8500000

[ Hazard Class ]:
9.0

[ HS Code ]:
29093038

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis, modification, and characterization of a family of homologues of exo-calix

J. Org. Chem. 65(17) , 5185-96, (2000)

A general strategy for the preparation of the family of exo-[n.m.n.m]metacyclophanes (n,m > or = 3) in 6-steps (starting from 2-bromoanisole) that utilizes a [2 + 2] approach to furnish the exo-metacy...

4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors.

Bioorg. Med. Chem. 22(2) , 917-26, (2014)

A series of unsymmetrically substituted biphenyl compounds was designed as alpha helical proteomimetics with the aim of inhibiting the binding of coactivator proteins to the nuclear hormone receptor c...

Diffusion coefficients of 2-fluoroanisole, 2-bromoanisole, allylbenzene and 1, 3-divinylbenzene at infinite dilution in supercritical carbon dioxide Suárez-Iglesias O, et al.

Fluid Phase Equilib. 260(2) , 279-86, (2007)