Inosine, 6-O-methyl-

Names

[ Name ]:
Inosine, 6-O-methyl-

[Synonym ]:
6-METHOXYPURINE RIBOSIDE
6-O-methylinosine
6-Methoxypurine-9-riboside

Biological Activity

[Description]:

6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.

[2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

Chemical & Physical Properties

[ Density]:
1.84g/cm3

[ Boiling Point ]:
610.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₄N₄O₅

[ Molecular Weight ]:
282.25

[ Flash Point ]:
323.1ºC

[ Exact Mass ]:
282.09600

[ PSA ]:
122.75000

[ Index of Refraction ]:
1.773

Precursor & DownStream

Precursor

DownStream

Related Compounds

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