1-(ISOPROPYLAMINO)-3-(2-METHOXYPHENOXY)PROPAN-2-OL

Names

[ Name ]:
1-(ISOPROPYLAMINO)-3-(2-METHOXYPHENOXY)PROPAN-2-OL

Biological Activity

[Description]:

Moprolol ((±)-Moprolol) is an beta-adrenergic receptor blocker, which can be used for research in essential hypertension[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

Beta-1 adrenergic receptor

[In Vitro]

l-Moprolol 是一种 β 阻断剂的 l-对映体，具有低负性肌力活性和轻度内在拟交感神经活性，可有效用于全身性高血压研究。在原发性开角型青光眼 (POAG) 或高眼压 (OHT) 模型中，局部应用l-Moprolol 可与噻洛尔一样有效地降低眼压 (IOP)，由于其对支气管肌肉缺乏活性，已成为抑制青光眼的一种很有前景的化合物[3]。

[References]

[1]. Borowiecki P, et al. Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol. RSC Adv. 2022 Aug 10;12(34):22150-22160.

[2]. Liu J, et al. beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. Clin Pharmacol Ther. 2006 Jul;80(1):23-32.

[3]. Rossetti L, et al. The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension. Graefes Arch Clin Exp Ophthalmol. 1994 Nov;232(11):670-4.

Chemical & Physical Properties

[ Density]:
1.054g/cm3

[ Boiling Point ]:
379.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₂₁NO₃

[ Molecular Weight ]:
239.31

[ Flash Point ]:
183.2ºC

[ Exact Mass ]:
239.15200

[ PSA ]:
50.72000

[ LogP ]:
1.82380

[ Index of Refraction ]:
1.509

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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