ethyl 3-ethoxy-2-(2,2,2-trifluoroacetyl)acrylate

Names

[ CAS No. ]:
571-55-1

[ Name ]:
ethyl 3-ethoxy-2-(2,2,2-trifluoroacetyl)acrylate

[Synonym ]:
Ethyl (2E)-2-(ethoxymethylene)-4,4,4-trifluoro-3-oxobutanoate
Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
MFCD02677683
Butanoic acid, 2-(ethoxymethylene)-4,4,4-trifluoro-3-oxo-, ethyl ester, (2E)-
ethyl 3-ethoxy-2-(2,2,2-trifluoroacetyl)acrylate

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
211.6±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₁F₃O₄

[ Molecular Weight ]:
240.176

[ Flash Point ]:
79.7±22.2 °C

[ Exact Mass ]:
240.060944

[ PSA ]:
52.60000

[ LogP ]:
3.69

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.406

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S23

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

High-speed microwave-assisted synthesis of the trifluoromethylpyrazol-derived canonical transient receptor potential (TRPC) channel inhibitor Pyr3.

ChemMedChem 4(11) , 1816-8, (2009)

Comparisons of pKa and log P values of some carboxylic and phosphonic acids: synthesis and measurement.

AAPS PharmSci 3(2) , E10, (2001)

The changes in the physiochemical properties accompanying the substitution of a phosphonic acid group for a carboxylic acid group on various heterocyclic platforms was determined. A series of low mole...

Synthesis and cardiotonic activity of 2-substituted 5-cyano-1,6-dihydro-6-oxo-3-pyridinecarboxylic acids and their methyl or ethyl esters.

Il Farmaco 47 , 427, (1992)

The synthesis of ethyl or methyl esters of 5-cyano-1,6-dihydro-6-oxo-3- pyridinecarboxylic acids carrying as 2-substituent a polar group such as CO2C2H5, (CH2)2CO2CH3, (CH2)3CO2C2H5, CH2OCH3, or CF3 g...