Tiapamil hydrochloride

Names

[ Name ]:
Tiapamil hydrochloride

[Synonym ]:
N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-[2-(3,4-dimethoxyphenyl)-1,1,3,3-tetraoxido-1,3-dithian-2-yl]-N-methyl-1-propanaminium chloride
2-(3,4-Dimethoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-N-methyl-1,3-dithiane-2-propanamine 1,1,3,3-tetraoxide hydrochloride
dimeditiapramine
N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-[2-(3,4-dimethoxyphenyl)-1,1,3,3-tetraoxido-1,3-dithian-2-yl]-N-methylpropan-1-amine hydrochloride (1:1)
S3R8JZ9DJH
TIAPAMIL HYDROCHLORIDE ANHYDROUS
1,3-Dithiane-2-propanaminium, 2-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-, chloride, 1,1,3,3-tetraoxide (1:1)
EINECS 260-511-1

Biological Activity

[Description]:

Tiapamil hydrochloride is a calcium channel blocker.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Cardiovascular Disease

[Target]

Calcium channel[1]

[In Vitro]

Tiapamil, a new calcium antagonist: hemodynamic effects in patients with acute myocardial infarction. Tiapamil is a new verapamil congener.Without precipitating left ventricular failure, Tiapamil reduced afterload and heart rate and maintained cardiac index while apparently improving diastolic compliance[1]. Tiapamil, a new calcium channel blocking agent with anti-anginal efficacy[2].

[References]

[1]. Eichler HG, et al. Tiapamil, a new calcium antagonist: hemodynamic effects in patients with acute myocardial infarction. Circulation. 1985 Apr;71(4):779-86.

[2]. Khurmi NS, et al. Tiapamil, a new calcium channel blocking agent for the treatment of effort induced chronic stableangina pectoris.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₈ClNO₈S₂

[ Molecular Weight ]:
592.165

[ Exact Mass ]:
591.172729

Related Compounds

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