SARS-CoV-2-IN-13

Names

[ Name ]:
SARS-CoV-2-IN-13

Biological Activity

[Description]:

SARS-CoV-2-IN-13 (compound 5) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.057 μM. SARS-CoV-2-IN-13 is a niclosamide analogue. SARS-CoV-2-IN-13 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[References]

[1]. Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₈Cl₂N₂O₄

[ Molecular Weight ]:
327.12

Related Compounds

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