56961-10-5

56961-10-5 structure

Name: SARS-CoV-2-IN-13
Chemical Name: SARS-CoV-2-IN-13
CAS Number: 56961-10-5
Molecular Formula: C₁₃H₈Cl₂N₂O₄
Molecular Weight: 327.12
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2022-07-01 19:29:20
Modify Date: 2025-08-25 09:06:32
SARS-CoV-2-IN-13 (compound 5) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.057 μM. SARS-CoV-2-IN-13 is a niclosamide analogue. SARS-CoV-2-IN-13 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

Name	SARS-CoV-2-IN-13

Description	SARS-CoV-2-IN-13 (compound 5) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.057 μM. SARS-CoV-2-IN-13 is a niclosamide analogue. SARS-CoV-2-IN-13 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
References	[1]. Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.

Molecular Formula	C₁₃H₈Cl₂N₂O₄
Molecular Weight	327.12