SARS-CoV-2-IN-10

Names

[ Name ]:
SARS-CoV-2-IN-10

Biological Activity

[Description]:

SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for therapeutic intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

SARS-CoV-2 3C-like proteas[1]

[References]

[1]. Dampalla CS, et al. Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies. J Med Chem. 2021;64(24):17846-17865.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₇F₂N₃O₅

[ Molecular Weight ]:
521.60

Related Compounds

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