UBP301

Names

[ Name ]:
UBP301

[Synonym ]:
ubp 301

Biological Activity

[Description]:

UBP301 is a potent and selective antagonist of kainate receptor with IC50 and KD of 164 μM and 5.94 μM, respectively. UBP301 has ∼30-fold selectivity of kainate receptor over AMPA receptor. UBP301 is the derivative of willardiine[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

164 μM (kainate receptor)[1]

[References]

[1]. More JC, et al. Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br J Pharmacol. 2003;138(6):1093-1100.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₄IN₃O₆

[ Molecular Weight ]:
459.19300

[ Exact Mass ]:
458.99300

[ PSA ]:
144.62000

[ LogP ]:
0.47330

Related Compounds

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