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N-acetyl Dapsone

Names

[ CAS No. ]:
565-20-8

[ Name ]:
N-acetyl Dapsone

[Synonym ]:
N-[4-(4-aminophenyl)sulfonylphenyl]acetamide
Mono-N-acetyl-4-4'-sulfonylbisbenzeneamine

Biological Activity

[Description]:

N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Tanaka K, et al. Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143(1-2):11-5.  

[2]. Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.

Chemical & Physical Properties

[ Density]:
1.362g/cm3

[ Boiling Point ]:
589.5ºC at 760mmHg

[ Melting Point ]:
238-240ºC

[ Molecular Formula ]:
C14H14N2O3S

[ Molecular Weight ]:
290.34

[ Flash Point ]:
310.3ºC

[ Exact Mass ]:
290.07300

[ PSA ]:
97.64000

[ LogP ]:
3.79500

[ Index of Refraction ]:
1.641

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AE7020000
CHEMICAL NAME :
Acetanilide, 4'-sulfanilyl-
CAS REGISTRY NUMBER :
565-20-8
BEILSTEIN REFERENCE NO. :
2746651
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H14-N2-O3-S
MOLECULAR WEIGHT :
290.36
WISWESSER LINE NOTATION :
ZR DSWR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 6,251,1951

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
37/38-41-43

[ Safety Phrases ]:
26-36/37/39

[ WGK Germany ]:
2

[ RTECS ]:
AE7020000

Precursor & DownStream

Precursor

DownStream

Related Compounds