(Pyr5)-Substance P (5-11)

Names

[ Name ]:
(Pyr5)-Substance P (5-11)

[Synonym ]:
5-Oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide
[pGlu5]-Substance P Fragment 5-11
pGlu-Gln-Phe-Phe-Gly-Leu-Met-NH2
L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-

Biological Activity

[Description]:

[Glp5] Substance P (5-11) is an octapeptide. [Glp5] Substance P (5-11) is one of the main substance P fragments in rat central nervous system (CNS). [Glp5] Substance P (5-11) locally modulates dopamine release in rat striatum[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vitro]

[Glp5] Substance P (5-11) (0.12 nM-10 μM; rat striatum) modifies spontaneous dopamine outflow with a significant increase in dopamine outflow at 0.1 nM and a smaller effect at 1 nM, whereas concentrations lower than 0.1 nM or higher than 1 nM failed to modify dopamine release. [Glp5] Substance P (5-11) and K+ has additive effect, promoting the release of dopamine[1].

[References]

[1]. Khan S, et, al. Substance P-(1-7) and substance P-(5-11) locally modulate dopamine release in rat striatum. Eur J Pharmacol. 1995 Aug 25;282(1-3):229-33.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1374.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₁H₅₇N₉O₉S

[ Molecular Weight ]:
852.011

[ Flash Point ]:
785.3±34.3 °C

[ Exact Mass ]:
851.400024

[ PSA ]:
315.18000

[ LogP ]:
0.64

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.581

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Biological activity of C-terminal partial sequences of substance P.

J. Med. Chem. 19 , 854, (1976)

Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) and the C-terminal partial sequences down to the tripeptide were synthesized by a solid-phase method. These peptides were assayed for vaso...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.