T16Ainh-A01

Names

[ Name ]:
T16Ainh-A01

[Synonym ]:
T16Ainh-A01

Biological Activity

[Description]:

T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC)[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel

Research Areas >> Others

[Target]

TMEM16A[1].

[References]

[1]. Fedigan S, et al. Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal. Pflugers Arch. 2017 Nov;469(11):1443-1455.

[2]. Namkung W, et al. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286(3):2365-74.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₀N₄O₃S₂

[ Molecular Weight ]:
416.52

[ Exact Mass ]:
416.09800

[ PSA ]:
154.26000

[ LogP ]:
4.56540

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport