2'-Aminoacetophenone

Names

[ CAS No. ]:
551-93-9

[ Name ]:
2'-Aminoacetophenone

[Synonym ]:
2-amino acetophenone
EINECS 209-002-8
2-Acetylaniline
MFCD00007717
Ethanone, 1-(2-aminophenyl)-
2'-Amonioacetophenone
2'-AminoActophenone
1-(2-Aminophenyl)ethanone
o-Acetylaniline
FEMA 3906
o-Aminoacetophenone
2`-Aminoacetophenone
ortho-Aminoacetophenone
o-Aminoacetylbenzene

Biological Activity

[Description]:

2'-Aminoacetophenone is an aromatic compound containing a ketone substituted by one alkyl group, and a phenyl group. 2'-Aminoacetophenone can be used as a breath biomarker for the detection of Ps. Aeruginosa infections in the cystic fibrosis lung[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Amy J Scott-Thomas , et al. 2-Aminoacetophenone as a Potential Breath Biomarker for Pseudomonas Aeruginosa in the Cystic Fibrosis Lung. BMC Pulm Med. 2010 Nov 7;10:56.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
251.8±13.0 °C at 760 mmHg

[ Melting Point ]:
20 °C

[ Molecular Formula ]:
C₈H₉NO

[ Molecular Weight ]:
135.163

[ Flash Point ]:
106.1±19.8 °C

[ Exact Mass ]:
135.068420

[ PSA ]:
43.09000

[ LogP ]:
1.62

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.571

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AM5775000

[ HS Code ]:
2914399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922399090

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Quantitative analysis of 2-aminoacetophenone in off-flavored wines by stable isotope dilution assay.

J. AOAC Int. 79(2) , 583-6, (1996)

Isotope dilution analysis was used to quantitate 2-aminoacetophenone in wines exhibiting the so-called untypical aging off-flavor. d3-Aminoacetophenone was synthesized and used as isotopomeric interna...

Glycosylation of aromatic amines III: Mechanistic implications of the pH-dependent glycosylation of various aromatic amines (kynurenine, 2'-aminoacetophenone, daptomycin, and sulfamethoxzaole).

J. Pharm. Sci. 98(12) , 4639-49, (2009)

Glycosylation reaction kinetics of a series of aromatic amines (kynurenine, 2'-aminoacetophenone, daptomycin, and sulfamethoxazole) was compared to propose a unifying reaction mechanism. Kinetic studi...

Purification and characterization of 2-aminoacetophenone reductase of newly isolated Burkholderia sp. YT.

J. Biosci. Bioeng. 104(5) , 416-9, (2007)

We found that a newly isolated Burkholderia sp. produced (R)-2-amino-1-phenylethanol from 2-aminoacetophenone, showing the high stereospecificity. NADPH-dependent 2-aminoacetophenone reductase purifie...