N-Nitrosodiethylamine

Names

[ CAS No. ]:
55-18-5

[ Name ]:
N-Nitrosodiethylamine

[Synonym ]:
MFCD00013890
Ethanamine, N-ethyl-N-nitroso-
DENA
Nitrosodiethylamine
Diethylnitrosoamine
N,N-Diethylnitrosoamine
Diethylamine,N-nitroso
NDEA
Diethylnitrosamine
EINECS 200-226-1
N-nitroso-diethylamine
N,N-diethylnitrous amide
Ethanamine,N-ethyl-N-nitroso
N-Nitrosodiethylamine
N-Ethyl-N-nitrosoethanamine

Biological Activity

[Description]:

N-Nitrosodiethylamine is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
173.9±9.0 °C at 760 mmHg

[ Melting Point ]:
<25℃

[ Molecular Formula ]:
C₄H₁₀N₂O

[ Molecular Weight ]:
102.135

[ Flash Point ]:
59.0±18.7 °C

[ Exact Mass ]:
102.079315

[ PSA ]:
32.67000

[ LogP ]:
0.42

[ Vapour Pressure ]:
1.7±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.442

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H350-H370

[ Precautionary Statements ]:
P201-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T,F

[ Risk Phrases ]:
45-22-39/23/24/25-23/24/25-11

[ Safety Phrases ]:
S53-S45-S36/37-S16

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
IA3500000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Articles

The Japanese toxicogenomics project: application of toxicogenomics.

Mol. Nutr. Food. Res. 54 , 218-27, (2010)

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted appr...

Novel study on N-nitrosamines as risk factors of cardiovascular diseases.

Biomed Res. Int. 2014 , 817019, (2014)

Millions of people are exposed daily to N-nitrosamines from different environmental sources. The present study aims at investigating the role of N-nitrosamines in the alteration of homocysteine, lipid...

Genetic targeting of sprouting angiogenesis using Apln-CreER.

Nat. Commun. 6 , 6020, (2015)

Under pathophysiological conditions in adults, endothelial cells (ECs) sprout from pre-existing blood vessels to form new ones by a process termed angiogenesis. During embryonic development, Apelin (A...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.