N-Nitrosodiethylamine

Names

[ CAS No. ]:
55-18-5

[ Name ]:
N-Nitrosodiethylamine

[Synonym ]:
MFCD00013890
Ethanamine, N-ethyl-N-nitroso-
DENA
Nitrosodiethylamine
Diethylnitrosoamine
N,N-Diethylnitrosoamine
Diethylamine,N-nitroso
NDEA
Diethylnitrosamine
EINECS 200-226-1
N-nitroso-diethylamine
N,N-diethylnitrous amide
Ethanamine,N-ethyl-N-nitroso
N-Nitrosodiethylamine
N-Ethyl-N-nitrosoethanamine

Biological Activity

[Description]:

N-Nitrosodiethylamine is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
173.9±9.0 °C at 760 mmHg

[ Melting Point ]:
<25℃

[ Molecular Formula ]:
C₄H₁₀N₂O

[ Molecular Weight ]:
102.135

[ Flash Point ]:
59.0±18.7 °C

[ Exact Mass ]:
102.079315

[ PSA ]:
32.67000

[ LogP ]:
0.42

[ Vapour Pressure ]:
1.7±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.442

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H350-H370

[ Precautionary Statements ]:
P201-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T,F

[ Risk Phrases ]:
45-22-39/23/24/25-23/24/25-11

[ Safety Phrases ]:
S53-S45-S36/37-S16

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
IA3500000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Articles

The Japanese toxicogenomics project: application of toxicogenomics.

Mol. Nutr. Food. Res. 54 , 218-27, (2010)

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted appr...

Novel study on N-nitrosamines as risk factors of cardiovascular diseases.

Biomed Res. Int. 2014 , 817019, (2014)

Millions of people are exposed daily to N-nitrosamines from different environmental sources. The present study aims at investigating the role of N-nitrosamines in the alteration of homocysteine, lipid...

Genetic targeting of sprouting angiogenesis using Apln-CreER.

Nat. Commun. 6 , 6020, (2015)

Under pathophysiological conditions in adults, endothelial cells (ECs) sprout from pre-existing blood vessels to form new ones by a process termed angiogenesis. During embryonic development, Apelin (A...