8-Oxyberberine
Names
[ CAS No. ]:
549-21-3
[ Name ]:
8-Oxyberberine
[Synonym ]:
8H-1,3-Benzodioxolo[5,6-a]benzo[g]quinolizin-8-one, 5,6-dihydro-9,10-dimethoxy-
8-oxoberberine
9,10-Dimethoxy-5,6-dihydro-8H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-8-one
9,10-Dimethoxy-5,6-dihydro-8H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-8-one
Ketoberberine
berberin-8-one
Berlambine
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
611.5±55.0 °C at 760 mmHg
[ Melting Point ]:
200-201ºC
[ Molecular Formula ]:
C20H17NO5
[ Molecular Weight ]:
351.353
[ Flash Point ]:
323.6±31.5 °C
[ Exact Mass ]:
351.110687
[ PSA ]:
58.92000
[ LogP ]:
3.87
[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C
[ Index of Refraction ]:
1.691
[ Water Solubility ]:
Insuluble (1.8E-3 g/L) (25 ºC)
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DS0180000
- CHEMICAL NAME :
- 8-Berbinone, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-
- CAS REGISTRY NUMBER :
- 549-21-3
- BEILSTEIN REFERENCE NO. :
- 0339209
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H17-N-O5
- MOLECULAR WEIGHT :
- 351.38
- WISWESSER LINE NOTATION :
- T G5 D6 C666 HO JO ONV IH&&T&&J RO1 SO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,486,1981
Safety Information
[ Hazard Codes ]:
Xi