Roemerine

Names

[ CAS No. ]:
548-08-3

[ Name ]:
Roemerine

[Synonym ]:
(6aR)-roemerine
(R)-(-)-roemerine
(-)-romerine
Roemerine
(-)-Aporheine
(-)-Remerine
(-)-Roemarine

Biological Activity

[Description]:

Roemerine, an aporphine alkaloid, isolated from the leaves of Annona senegalensis, functions by interacting with P-glycoprotein. Roemerine reverses the multidrug-resistance phenotype with cultured cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[References]

[1]. M You, et al. (-)-Roemerine, an Aporphine Alkaloid From Annona Senegalensis That Reverses the Multidrug-Resistance Phenotype With Cultured Cells. J Nat Prod. 1995 Apr;58(4):598-604.

Chemical & Physical Properties

[ Density]:
1.269±0.06 g/cm3 (20 ºC 760 Torr)

[ Melting Point ]:
102-103 ºC

[ Molecular Formula ]:
C₁₈H₁₇NO₂

[ Molecular Weight ]:
279.33300

[ Exact Mass ]:
279.12600

[ PSA ]:
21.70000

[ LogP ]:
3.10530

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds

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