BMS-433771 dihydrochloride hydrate

Names

[ Name ]:
BMS-433771 dihydrochloride hydrate

Biological Activity

[Description]:

BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> RSV

[Target]

EC50: 20 nM (RSV)[1]

[In Vitro]

BMS-433771 dihydrochloride hydrate 对 A 组和 B 组 RSV 均具有抑制作用，平均 EC50 为 20 nM[1]。 BMS-433771 dihydrochloride hydrate 可抑制病毒 F 蛋白诱导的膜融合[1]。

[In Vivo]

BMS-433771 dihydrochloride hydrate (口服；1-200 mg/kg；每天 1 或 2 次，共 4 天) 通过口服给药显示出预防效果，但两种啮齿动物模型之间具有相当大的药效学差异[2] .

[References]

[1]. Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother

[2]. Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₇Cl₂N₅O₃

[ Molecular Weight ]:
468.38

Related Compounds

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