543700-67-0

543700-67-0 structure

Name: BMS-433771 dihydrochloride hydrate
Chemical Name: BMS-433771 dihydrochloride hydrate
CAS Number: 543700-67-0
Molecular Formula: C₂₁H₂₇Cl₂N₅O₃
Molecular Weight: 468.38
Catalog: Signaling Pathways Anti-infection RSV
Create Date: 2023-06-18 16:45:56
Modify Date: 2024-01-12 10:27:32
BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease[1][2].

Name	BMS-433771 dihydrochloride hydrate

Description	BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> RSV
Target	EC50: 20 nM (RSV)[1]
In Vitro	BMS-433771 dihydrochloride hydrate 对 A 组和 B 组 RSV 均具有抑制作用，平均 EC50 为 20 nM[1]。 BMS-433771 dihydrochloride hydrate 可抑制病毒 F 蛋白诱导的膜融合[1]。
In Vivo	BMS-433771 dihydrochloride hydrate (口服；1-200 mg/kg；每天 1 或 2 次，共 4 天) 通过口服给药显示出预防效果，但两种啮齿动物模型之间具有相当大的药效学差异[2] .
References	[1]. Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother [2]. Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54.

Molecular Formula	C₂₁H₂₇Cl₂N₅O₃
Molecular Weight	468.38