Camylofine

Names

[ CAS No. ]:
54-30-8

[ Name ]:
Camylofine

[Synonym ]:
Adopon
Camylofine
Sintespasmil
Acamylophenine
Spasmocan
Novospasmin
Camylopin
Navadyl
Belosin
Camylofin

Biological Activity

[Description]:

Camylofin is an antimuscarinic, is a smooth muscle relaxant

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.987g/cm3

[ Boiling Point ]:
408.4ºC at 760mmHg

[ Melting Point ]:
25°C

[ Molecular Formula ]:
C₁₉H₃₂N₂O₂

[ Molecular Weight ]:
320.47000

[ Flash Point ]:
200.8ºC

[ Exact Mass ]:
320.24600

[ PSA ]:
41.57000

[ LogP ]:
3.63930

[ Index of Refraction ]:
1.502

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MB9625000

CHEMICAL NAME :: Glycine, N-(2-(diethylamino)ethyl)-2-phenyl-, isopentyl ester

CAS REGISTRY NUMBER :: 54-30-8

BEILSTEIN REFERENCE NO. :: 2816984

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H32-N2-O2

MOLECULAR WEIGHT :: 320.53

WISWESSER LINE NOTATION :: 2N2&2MYR&VO2Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DMWOAX Deutsche Medizinische Wochenschrift. (Stuttgart, Fed. Rep. Ger.) V.1-104, 1875-1979. Volume(issue)/page/year: 76,479,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 76,1175,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 610 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 59,113,1963

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MB9625000

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Determination of the analgesic components of Spasmomigraine tablet by liquid chromatography with ultraviolet detection.

J. AOAC Int. 90(1) , 94-101, (2007)

A procedure was developed for the determination of the analgesic components of Spasmomigraine tablets, which are ergotamine (I), propyphenazone (II), caffeine (III), camylofin (IV), and mecloxamine (V...

Use of anafortan intravenous injection for treatment of colicky pain.

J. Indian Med. Assoc. 98(8) , 479, 482, (2000)

Development and characterization of colon specific drug delivery system bearing 5-ASA and Camylofine dihydrochloride for the treatment of ulcerative colitis.

J. Drug Target. 18(8) , 589-601, (2010)

The treatment of ulcerative colitis (inflammatory bowel disease, IBD) has been achieved by using colon specific drug delivery system bearing 5-ASA and Camylofine dihydrochloride. Chitosan microspheres...