1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one

Names

[ Name ]:
1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one

[Synonym ]:
Dibenz[cd,f]indol-4(5H)-one, 1,2,9-trimethoxy-
3,4,6-trimethoxyaristolactame
aristolactam A II
Aristololactam B III
1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one
aristololactam A-II
Dibenz(cd,f)indol-4(5H)-one,2-hydroxy-1-methoxy
aristolactam BIII

Biological Activity

[Description]:

Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

Research Areas >> Inflammation/Immunology

[References]

[1]. Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
462.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₅NO₄

[ Molecular Weight ]:
309.316

[ Flash Point ]:
233.7±28.7 °C

[ Exact Mass ]:
309.100098

[ PSA ]:
60.28000

[ LogP ]:
3.23

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.681

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.