4-Chloroacetanilide
Names
[ CAS No. ]:
539-03-7
[ Name ]:
4-Chloroacetanilide
[Synonym ]:
N-(4-Chlorophenyl)acetamide
4‘-Chloroacetanilide
EINECS 208-707-8
4'-chloroacetanilide
p-Chloroacetanilide
MFCD00000612
Acetamide, N-(4-chlorophenyl)-
Acetic acid 4-chloroanilide
4-Chloroacetanilide
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
335.0±25.0 °C at 760 mmHg
[ Melting Point ]:
176-178 °C(lit.)
[ Molecular Formula ]:
C8H8ClNO
[ Molecular Weight ]:
169.608
[ Flash Point ]:
156.4±23.2 °C
[ Exact Mass ]:
169.029449
[ PSA ]:
29.10000
[ LogP ]:
2.05
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.591
[ Water Solubility ]:
dioxane: 50 mg/mL hot, clear
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AE1001000
- CHEMICAL NAME :
- Acetanilide, 4'-chloro-
- CAS REGISTRY NUMBER :
- 539-03-7
- BEILSTEIN REFERENCE NO. :
- 0509638
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C8-H8-Cl-N-O
- MOLECULAR WEIGHT :
- 169.62
- WISWESSER LINE NOTATION :
- GR DMV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 245 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 730 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 2500 ug/plate
- REFERENCE :
- PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 10,174,1979
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
AE1001000
[ HS Code ]:
2924299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2924299090
[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
J. AOAC Int. 89(1) , 201-9, (2006)
U.S. Environmental Protection Agency (EPA) Method 535 has been developed in order to provide a method for the analysis of "Alachlor ESA and other acetanilide degradation products," which are listed on...
Toxicology laboratory analysis and human exposure to p-chloroaniline.Clin. Toxicol. (Phila.) 47(2) , 132-6, (2009)
p-Chloroaniline is more potent at producing methemoglobin than aniline in animal models. This case highlights the clinical presentation of an inhalation exposure to p-chloroaniline and associated labo...
Structural characterization and function determination of a nonspecific carboxylate esterase from the amidohydrolase superfamily with a promiscuous ability to hydrolyze methylphosphonate esters.Biochemistry 53(21) , 3476-85, (2014)
The uncharacterized protein Rsp3690 from Rhodobacter sphaeroides is a member of the amidohydrolase superfamily of enzymes. In this investigation the gene for Rsp3690 was expressed in Escherichia coli ...