(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol
Names
[ CAS No. ]:
53732-47-1
[ Name ]:
(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol
[Synonym ]:
(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol
S-Tetralol
(S)-(+)-α-Tetralol
(S)-1,2,3,4-Tetrahydronaphthalen-1-ol
(1S)-1,2,3,4-Tetrahydronaphthalen-1-ol
MFCD00063006
1-Naphthalenol, 1,2,3,4-tetrahydro-, (1S)-
(1S)-1,2,3,4-Tetrahydro-1-naphthalenol
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
254.8±0.0 °C at 760 mmHg
[ Melting Point ]:
37-39ºC
[ Molecular Formula ]:
C10H12O
[ Molecular Weight ]:
148.202
[ Flash Point ]:
99.9±11.0 °C
[ Exact Mass ]:
148.088821
[ PSA ]:
20.23000
[ LogP ]:
2.05
[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.585
[ Storage condition ]:
0-10°C
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
QL5075000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Med. Chem. 49 , 1818-27, (2006)
A set of 28 enantiomers comprising rigid and flexible secondary alcohols was synthesized by the asymmetric Corey-Bakshi-Shibata reduction. The enantiomerically pure alcohols were subjected to enzymati...
Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme.Bioorg. Med. Chem. Lett. 20 , 5274-6, (2010)
A comparison of the structures and kinetic properties of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) and its mutant enzymes (Leu308Val and Leu308Ala) indicates that Leu308 is a selectivity det...