Diperodon (hydrochloride)

Names

[ CAS No. ]:
537-12-2

[ Name ]:
Diperodon (hydrochloride)

[Synonym ]:
3-(1-Piperidinyl)-1,2-propanediol bis(phenylcarbamate)
Diperocaine
EINECS 208-659-8
Proctodon
Diperodon HCl
DIPERODON HYDROCHLORIDE
Diothane hydrochloride
Diperdon hydrochloride
Diperodon (hydrochloride)

Biological Activity

[Description]:

Diperodon is a local anaesthetics, by the action of hydrolazes in blood serum is decomposed.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Cizmárik J, et al. Study of local anaesthetics. Part 133. Determination of diperodon in blood serum in vitro by the HPLC method. Acta Pol Pharm. 1996 May-Jun;53(3):167-169.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
502ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₈ClN₃O₄

[ Molecular Weight ]:
433.92800

[ Flash Point ]:
257.4ºC

[ Exact Mass ]:
433.17700

[ PSA ]:
79.90000

[ LogP ]:
5.22420

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ1101000

CHEMICAL NAME :: 1,2-Propanediol, 3-piperidino-, dicarbanilate, hydrochloride

CAS REGISTRY NUMBER :: 537-12-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H27-N3-O4.Cl-H

MOLECULAR WEIGHT :: 433.98

WISWESSER LINE NOTATION :: T6NTJ A1YOVMR&&1OVMR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 890 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 48,398,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,255,1933

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,255,1933

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 47,255,1933

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TZ1101000

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Study of local anaesthetics. Part 133. Determination of diperodon in blood serum in vitro by the HPLC method.

Acta Pol. Pharm. 53(3) , 167-9, (1996)

A local anaesthetics diperodon by the action of hydrolazes in blood serum is decomposed. A method for its determination in blood serum in vitro has been worked out. It was found that during the first ...

[HPLC determination of diperodon enantiomers in blood serum by using teicoplanin chiral stationary phase].

Ceska. Slov. Farm. 53(5) , 225-7, (2004)

The chiral stationary phase on the base of teicoplanin and the polar-organic mobile phase methanol/acetonitrile/acetic acid/triethylamine 45/55/0.3/0.2 was used for the separation of diperodon enantio...

In vitro study of enzymatic hydrolysis of diperodon enantiomers in blood serum by two-dimensional LC.

J. Pharm. Biomed. Anal. 30(3) , 875-80, (2002)

An on-line coupled HPLC system is described for the determination of the enantiomers of diperodon in blood serum. The method involves three steps: (i) off-line preconcentration and clean-up, (ii) sepa...