Chlamydocin

Names

[ Name ]:
Chlamydocin

[Synonym ]:
SL-3440
Antibiotic SL-3440
2-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-]

Biological Activity

[Description]:

Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC:1.3 nM (IC50)

[In Vitro]

Chlamydocin is originally isolated from the fungus Diheterospora chlamydosporia. Chlamydocin exhibits a broad spectrum of antiproliferative activity toward various cancer cell lines, irrespective of their p53 status. The antiproliferative activity of Chlamydocin is accompanied by accumulation of hyperacetylated histones H3 and H4, induction of p21cip1/waf1, and accumulation of cells in G2/M phase of the cell cycle[1].

[References]

[1]. De Schepper S, et al. Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin. J Pharmacol Exp Ther. 2003;304(2):881-888.

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
861.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₃₈N₄O₆

[ Molecular Weight ]:
526.62500

[ Flash Point ]:
475ºC

[ Exact Mass ]:
526.27900

[ PSA ]:
137.21000

[ LogP ]:
1.94080

[ Index of Refraction ]:
1.589

Related Compounds

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