53342-16-8

53342-16-8 structure

Name: Chlamydocin
Chemical Name: chlamydocin
CAS Number: 53342-16-8
Molecular Formula: C₂₈H₃₈N₄O₆
Molecular Weight: 526.62500
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-07-06 17:47:07
Modify Date: 2024-01-02 14:10:50
Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3[1].

Name	chlamydocin
Synonyms	SL-3440 Antibiotic SL-3440 2-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-]

Description	Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC:1.3 nM (IC50)
In Vitro	Chlamydocin is originally isolated from the fungus Diheterospora chlamydosporia. Chlamydocin exhibits a broad spectrum of antiproliferative activity toward various cancer cell lines, irrespective of their p53 status. The antiproliferative activity of Chlamydocin is accompanied by accumulation of hyperacetylated histones H3 and H4, induction of p21cip1/waf1, and accumulation of cells in G2/M phase of the cell cycle[1].
References	[1]. De Schepper S, et al. Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin. J Pharmacol Exp Ther. 2003;304(2):881-888.