DiSC3(5)

Names

[ Name ]:
DiSC3(5)

[Synonym ]:
MFCD00075033
3-Propyl-2-[5-[3-propyl-2(3H)-benzothiazolylidene]-1,3-pentadienyl]benzothiazolium Iodide
3,3'-Dipropylthiadicarbocyanine iodide
3,3'-Dipropylthiadicarbocyanine iodide,DiSC3(5)
5-(3-Propylbenzothiazol-2-ylidene)-1-(3-propylbenzothiazolium-2-yl)-1,3-pentadiene Iodide

Biological Activity

[Description]:

DiSC3(5) is a fluorescent probe often used as a tracer dye to assess the mitochondrial membrane potential[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Yamamoto T, et al. Multiple effects of DiS-C3(5) on mitochondrial structure and function. Eur J Biochem. 2004;271(17):3573-3579.

Chemical & Physical Properties

[ Melting Point ]:
245ºC (dec.)(lit.)

[ Molecular Formula ]:
C₂₅H₂₇IN₂S₂

[ Molecular Weight ]:
546.53000

[ Exact Mass ]:
546.06600

[ PSA ]:
65.29000

[ LogP ]:
3.36020

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY.

J. Biol. Chem. 291 , 13864-74, (2016)

Bacterial membranes are highly organized, containing specific microdomains that facilitate distinct protein and lipid assemblies. Evidence suggests that cardiolipin molecules segregate into such micro...

A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector.

Biochim. Biophys. Acta 1837(10) , 1739-47, (2014)

Limited uncoupling of oxidative phosphorylation is known to be beneficial in various laboratory models of diseases. The search for cationic uncouplers is promising as their protonophorous effect is se...

Myricetin inhibits the release of glutamate in rat cerebrocortical nerve terminals.

J. Med. Food 18 , 516-23, (2015)

The excessive release of glutamate is a critical element in the neuropathology of acute and chronic brain disorders. The purpose of the present study was to investigate the effect and possible mechani...