Tropinone

Names

[ CAS No. ]:
532-24-1

[ Name ]:
Tropinone

[Synonym ]:
Tropanon
N-methyl-3-tropanone
8-azabicyclo[3.2.1]octan-3-one, 8-methyl-, (1S,5S)-
8-Methyl-8-azabicyclo[3.2.1]-3-octanone
3-tropinone
tropan-3-one
(1S,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-one
Tropinone
EINECS 208-530-6
Tropinon
Tropanone
3-Tropanone
8-Azabicyclo[3.2.1]octan-3-one, 8-methyl-, (1R,5S)-
(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-one
1αH,5αH-tropan-3-one
8-methyl-8-aza-bicyclo[3.2.1]octan-3-one
MFCD00005549
1αH,5αH-Tropan-3-one (8CI)
TROPIONONE
8-methyl-8-azabicyclo[3.2.1]oct-3-one
8-methyl-8-azabicyclo[3.2.1]octane-3-one

Biological Activity

[Description]:

Tropinone, an alkaloid, acts as a synthetic intermediate to Atropine[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Bedewitz MA, et al. Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization. Nat Commun. 2018 Dec 11;9(1):5281. doi: 10.1038/s41467-018-07671-3.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
217.1±0.0 °C at 760 mmHg

[ Melting Point ]:
40-44 °C(lit.)

[ Molecular Formula ]:
C₈H₁₃NO

[ Molecular Weight ]:
139.195

[ Flash Point ]:
90.0±0.0 °C

[ Exact Mass ]:
139.099716

[ PSA ]:
20.31000

[ LogP ]:
0.07

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.505

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S23-S24/25-S36/37/39-S26-S22

[ RIDADR ]:
1544

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Toxicity of field bindweed (Convolvulus arvensis) to mice.

Vet. Hum. Toxicol. 37(5) , 452-4, (1995)

The effects of feeding high and low doses of field bindweed (Convolvulus arvensis) to mice were investigated. Bindweed contains several alkaloids, including pseudotropine, and lesser amounts of tropin...

Synthesis and applications of masked oxo-sulfinamides in asymmetric synthesis.

Org. Biomol. Chem. 10(26) , 5021-31, (2012)

This short perspective reports on the synthesis and applications of a class of chiral amino carbonyl compounds, masked oxo-sulfinamides where the amine is protected with an N-sulfinyl moiety and the c...

Biosynthesis of calystegines: 15N NMR and kinetics of formation in root cultures of Calystegia sepium.

Phytochemistry 62(3) , 325-32, (2003)

Calystegines are nortropane alkaloids bearing between three and five hydroxyl groups in various positions. [15N]Tropinone was administered to root cultures of Calystegia sepium and the incorporation i...