Euxanthone

Names

[ CAS No. ]:
529-61-3

[ Name ]:
Euxanthone

[Synonym ]:
1,7-Dihydroxy-9H-xanthen-9-one
1,7-dihydroxyxanthen-9-one
purrenone
1,7-Dihydroxyxanthone
eyxanthone
Euxanthone
1,7-Dihydroxy-xanthen-9-on
1,7-dihydroxy-xanthen-9-one
9H-Xanthen-9-one, 1,7-dihydroxy-

Biological Activity

[Description]:

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering Autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Neurological Disease

[In Vitro]

Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力，并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]。 Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]。 Cell Migration Assay [1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Inhibited cell migration at 24 hr. Western Blot Analysis[1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.

[In Vivo]

在肺转移模型中，Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]。 Euxanthone（30-60 mg/kg；口服；每天一次；持续 7 天）治疗使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]。 Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] Dosage: 30 mg/kg, 60 mg/kg Administration: p.o.;once a day; for 7 days Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.

[References]

[1]. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408.

[2]. Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455.

[3]. aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
472.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₈O₄

[ Molecular Weight ]:
228.200

[ Flash Point ]:
191.1±22.2 °C

[ Exact Mass ]:
228.042252

[ PSA ]:
70.67000

[ LogP ]:
1.92

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.718

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%