BioBioPha
China
Product Name: Euxanthone
Price: ￥2500.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Euxanthone
Price: ￥3520.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,7-DIHYDROXY-9H-XANTHEN-9-ONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

529-61-3

529-61-3 structure

529-61-3 structure

Name: Euxanthone
Chemical Name: euxanthone
CAS Number: 529-61-3
Molecular Formula: C₁₃H₈O₄
Molecular Weight: 228.200
Catalog: Natural product Xanthone
Create Date: 2018-04-27 08:00:00
Modify Date: 2024-01-02 14:58:41
Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering Autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].

Name	euxanthone
Synonyms	1,7-Dihydroxy-9H-xanthen-9-one 1,7-dihydroxyxanthen-9-one purrenone 1,7-Dihydroxyxanthone eyxanthone Euxanthone 1,7-Dihydroxy-xanthen-9-on 1,7-dihydroxy-xanthen-9-one 9H-Xanthen-9-one, 1,7-dihydroxy-

Description	Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering Autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease
In Vitro	Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力，并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]。 Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]。 Cell Migration Assay [1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Inhibited cell migration at 24 hr. Western Blot Analysis[1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
In Vivo	在肺转移模型中，Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]。 Euxanthone（30-60 mg/kg；口服；每天一次；持续 7 天）治疗使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]。 Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] Dosage: 30 mg/kg, 60 mg/kg Administration: p.o.;once a day; for 7 days Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
References	[1]. Xiaodong Chen, et al. Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. Anat Rec (Hoboken). 2019 Aug;302(8):1399-1408. [2]. Wei Sun, et al. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress. Cent Eur J Immunol. 2021;46(4):446-455. [3]. aicheng Yuan, et al. Euxanthone Attenuates Aβ1-42-Induced Oxidative Stress and Apoptosis by Triggering Autophagy. J Mol Neurosci. 2018 Dec;66(4):512-523.

Density	1.5±0.1 g/cm3
Boiling Point	472.6±45.0 °C at 760 mmHg
Molecular Formula	C₁₃H₈O₄
Molecular Weight	228.200
Flash Point	191.1±22.2 °C
Exact Mass	228.042252
PSA	70.67000
LogP	1.92
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.718

HS Code	2932999099

Precursor 10
490-79-9 108-46-3 244121-75-3 2150-45-0
123-31-9 529-49-7 89-86-1 127506-72-3
88331-62-8 7664-93-9
DownStream 6
92-83-1 88331-62-8 123-31-9 82-71-3
144-62-7 96935-32-9

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%